Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms

Anjaparavanda P. Naren, Deborah J. Nelson, Weiwen Xie, Biljana Jovov, Jonathan Pevsner, Mark K. Bennett, Dale J. Benos, Michael W. Quick and Kevin L. Kirk ()
Additional contact information
Anjaparavanda P. Naren: Gregory Fleming James Cystic Fibrosis Research Center
Deborah J. Nelson: University of Chicago
Weiwen Xie: University of Chicago
Biljana Jovov: Gregory Fleming James Cystic Fibrosis Research Center
Jonathan Pevsner: Kennedy Krieger Institute and The Johns Hopkins University School of Medicine
Mark K. Bennett: University of California
Dale J. Benos: Gregory Fleming James Cystic Fibrosis Research Center
Michael W. Quick: University of Alabama at Birmingham
Kevin L. Kirk: Gregory Fleming James Cystic Fibrosis Research Center

Nature, 1997, vol. 390, issue 6657, 302-305

Abstract: Abstract The cystic fibrosis gene encodes a cyclic AMP-gated chloride channel (CFTR) that mediates electrolyte transport across the luminal surfaces of a variety of epithelial cells1,2,3,4. The molecular mechanisms that modulate CFTR activity in epithelial tissues are poorly understood. Here we show that CFTR is regulated by an epithelially expressed syntaxin (syntaxin 1A), a membrane protein that also modulates neurosecretion5,6,7 and calcium-channel gating8,9,10,11 in brain. Syntaxin 1A physically interacts with CFTR chloride channels and regulates CFTR-mediated currents both in Xenopus oocytes and in epithelial cells that normally express these proteins. The physical and functional interactions between syntaxin 1A and CFTR are blocked by a syntaxin-binding protein of the Munc18 protein family (also called n-Sec1; refs 12,13,14). Our results indicate that CFTR function in epithelial cells is regulated by an interplay between syntaxin and Munc18 isoforms.

Date: 1997
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/36882 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:390:y:1997:i:6657:d:10.1038_36882

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/36882

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().