Unravelling gene interactions

Sarah P. Otto ()
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Sarah P. Otto: University of British Columbia

Nature, 1997, vol. 390, issue 6658, 343-343

Abstract: How do genes interact to create and maintain a whole organism? A handle on this question comes from various experiments onEscherichia coli, some of which involve creating random pairs of mutations and comparing the results on the bacterium's 'fitness' with those of bacteria with only one of the mutations. In about half of the cases fitness was clearly different, meaning that many apparently unrelated genes affect each other's function. The implications are considerable, not least for those interested in evolutionary theories of sex — a popular version of which holds that sex allows the efficient elimination of deleterious mutations.

Date: 1997
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DOI: 10.1038/36996

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