Melanocortin receptors in leptin effects

Randy J. Seeley (), Keith A. Yagaloff, Stewart L. Fisher, Paul Burn, Todd E. Thiele, Gertjan van Dijk, Denis G. Baskin and Michael W. Schwartz
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Randy J. Seeley: University of Cincinnati
Keith A. Yagaloff: Hoffmann-La Roche Inc.
Stewart L. Fisher: Hoffmann-La Roche Inc.
Paul Burn: Hoffmann-La Roche Inc.
Todd E. Thiele: Medicine and Biological Structure, and Puget Sound VA Health Care System, Harborview Medical Center, University of Washington
Gertjan van Dijk: Medicine and Biological Structure, and Puget Sound VA Health Care System, Harborview Medical Center, University of Washington
Denis G. Baskin: Medicine and Biological Structure, and Puget Sound VA Health Care System, Harborview Medical Center, University of Washington
Michael W. Schwartz: Medicine and Biological Structure, and Puget Sound VA Health Care System, Harborview Medical Center, University of Washington

Nature, 1997, vol. 390, issue 6658, 349-349

Abstract: Abstract Leptin acts on the central nervous system to cause a reduction in food intake and body weight1,2. The melanocortin system in the brain is also implicated in energy homeostasis, with agonists of the melanocortin-4 (MC4) receptor reducing food intake3 and targeted mutation of the MC4 receptor causing obesity4. We now show that MC4 receptor signalling is an important mediator of leptin's effects on food intake and body weight, demonstrating a link between the two systems.

Date: 1997
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DOI: 10.1038/37016

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