TGF-β signalling from cell membrane to nucleus through SMAD proteins

Carl-Henrik Heldin, Kohei Miyazono and Peter ten Dijke
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Carl-Henrik Heldin: the Ludwig Institute for Cancer Research
Kohei Miyazono: The Cancer Institute
Peter ten Dijke: the Ludwig Institute for Cancer Research

Nature, 1997, vol. 390, issue 6659, 465-471

Abstract: Abstract The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-β (TGF-β) signals from the cell membrane to the nucleus. Pathway-restricted SMADs are phosphorylated by specific cell-surface receptors that have serine/threonine kinase activity, then they oligomerize with the common mediator Smad4 and translocate to the nucleus where they direct transcription to effect the cell's response to TGF-β. Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs.

Date: 1997
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DOI: 10.1038/37284

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