Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

Emanuel F. Petricoin, Satoshi Ito, Brandi L. Williams, Susette Audet, Louis F. Stancato, Ana Gamero, Kathleen Clouse, Philip Grimley, Arthur Weiss, Judy Beeler, David S. Finbloom, Elizabeth W. Shores, Robert Abraham and Andrew C. Larner ()
Additional contact information
Emanuel F. Petricoin: Center for Biologics, Evaluation and Research, FDA
Satoshi Ito: Center for Biologics, Evaluation and Research, FDA
Brandi L. Williams: Mayo Clinic
Susette Audet: Center for Biologics, Evaluation and Research, FDA
Louis F. Stancato: Center for Biologics, Evaluation and Research, FDA
Ana Gamero: Research Institute, Cleveland Clinic Foundation
Kathleen Clouse: Center for Biologics, Evaluation and Research, FDA
Philip Grimley: USUHS
Arthur Weiss: University of California at San Francisco
Judy Beeler: Center for Biologics, Evaluation and Research, FDA
David S. Finbloom: Center for Biologics, Evaluation and Research, FDA
Elizabeth W. Shores: Center for Biologics, Evaluation and Research, FDA
Robert Abraham: Mayo Clinic
Andrew C. Larner: Center for Biologics, Evaluation and Research, FDA

Nature, 1997, vol. 390, issue 6660, 629-632

Abstract: Abstract Signal transduction through both cytokine and lymphocyte antigen receptors shares some common pathways by which they initiate cellular responses, such as activation of mitogen-activated protein kinase(s)1,2. However, other signalling components appear to be uniquely coupled to each receptor. For example, the interferon receptors transduce regulatory signals through the JAK/STAT pathway, resulting in an inhibition of growth and of antiviral effects, whereas this pathway apparently plays no role in T-cell-receptor (TCR)-dependent gene expression3,4. Conversely, signal transduction through the TCR requires the tyrosine kinases Lck and ZAP-70 and the tyrosine phosphatase CD45 (ref. 5). Here we show that, unexpectedly, transmission of growth-inhibitory signals by interferon-α (IFN-α) in T cells requires the expression and association of CD45, Lck and ZAP-70 with the IFN-α-receptor signalling complex.

Date: 1997
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/37648 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:390:y:1997:i:6660:d:10.1038_37648

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/37648

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().