B lymphocytes and neuroinvasion

Paul Brown ()
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Paul Brown: the Laboratory of CNS Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health

Nature, 1997, vol. 390, issue 6661, 662-663

Abstract: How does consumption of meat products infected with bovine spongiform encephalopathy (BSE) lead to development of Creutzfeldt-Jakob disease (CJD)? Studies of the brain, spleen and marrow of many immunodeficient mouse lines indicate that differentiated B lymphocytes are important for neuroinvasion. This discovery has implications for therapies against CJD, and also for the broader public-health issue of screening blood products against possible infection.

Date: 1997
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DOI: 10.1038/37733

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