An endonuclease at last

Andrew Wyllie
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Andrew Wyllie: Sir Alastair Currie CRC Laboratories, University of Edinburgh

Nature, 1998, vol. 391, issue 6662, 20-21

Abstract: One of the main clues that apoptosis is a ‘programmed’ cell death is the production of ‘chromatin ladders’ — digestion of DNA into regularly sized fragments. The nuclease responsible for this cleavage has now been identified. Found as an inactive form within the cytoplasm, this nuclease is activated by caspase-3 digestion, earning it the name caspase-activated DNAse (CAD). The same group has also identified a protein that binds to, and inactivates, CAD, and the overall picture seems to be that this protein, ICAD (for inhibitor of CAD), releases CAD after caspase-3 digestion.

Date: 1998
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DOI: 10.1038/34040

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