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Coupling herpesvirus to angiogenesis

Chris Boshoff ()
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Chris Boshoff: the Chester Beatty Laboratories, Institute of Cancer Research

Nature, 1998, vol. 391, issue 6662, 24-25

Abstract: Kaposi's sarcoma-associated herpesvirus has been detected in every Kaposi's sarcoma biopsy, yet nobody knows how the virus contributes to the tumour-cell formation that is associated with the disease. The key, it now seems, may lie with the so-called G-protein-coupled receptor. This protein is encoded by the virus, and it induces the production of a powerful factor that stimulates the formation of blood vessels to nourish the tumour cells.

Date: 1998
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DOI: 10.1038/34054

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