Artificial tissues

Philip Ball

Nature, 1998, vol. 391, issue 6663, 128-128

Abstract: Primitive artificial livers are already used for supporting liver-failure patients awaiting a transplant. Unfortunately, the liver is a highly structured organ, and its function is poorly reproduced by a random culture of hepatocytes (liver cells) and tissue-forming fibroblast cells. But a marriage of cell biology with microfabrication can do better. By using photolithography to pattern films of collagen on a borosilicate wafer, hepatocytes and fibroblasts can be made to grow in a controlled array, which can be adjusted to gain the best performance from these artificial livers.

Date: 1998
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DOI: 10.1038/34303

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