A mechanism for all polymerases

Thomas A. Steitz
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Thomas A. Steitz: Yale University

Nature, 1998, vol. 391, issue 6664, 231-232

Abstract: Replication of the genome is one of the most fundamental of biological activities, hence the interest in the mechanism by which the enzymes concerned -- the polynucleotide polymerases -- carry out the process. The co-crystal structures of the DNA polymerase that replicates bacteriophage T7, and of theBacillus stearothermophilusDNA polymerase large fragment, provide significant insights into the catalytic mechanism, fidelity and processivity of DNA polymerases.

Date: 1998
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DOI: 10.1038/34542

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