A technical KO of amyloid-β peptide

Christian Haass () and Dennis J. Selkoe ()
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Christian Haass: Central Institute for Mental Health
Dennis J. Selkoe: the Center for Neurologic Diseases, Harvard Medical School, Brigham and Womens Hospital

Nature, 1998, vol. 391, issue 6665, 339-340

Abstract: Mutations in the presenilin-1 gene (PS1) cause an aggressive form of familial Alzheimer's disease, and a new study goes some way to showing how. The authors created PS1 knockout mice, and found that they produced 80 per cent less amyloid-beta peptide (the protein that accumulates to form senile plaques) than normal mice. They propose that presenilin-1 normally stimulates production of amyloid-beta peptide by activating alpha-secretase-mediated cleavage of the amyloid precursor protein.

Date: 1998
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DOI: 10.1038/34800

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