Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Andrei Glinka, Wei Wu, Hajo Delius, A. Paula Monaghan, Claudia Blumenstock and Christof Niehrs
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Andrei Glinka: Deutsches Krebsforschungszentrum
Wei Wu: Deutsches Krebsforschungszentrum
Hajo Delius: Deutsches Krebsforschungszentrum
A. Paula Monaghan: Deutsches Krebsforschungszentrum
Claudia Blumenstock: Deutsches Krebsforschungszentrum
Christof Niehrs: Deutsches Krebsforschungszentrum

Nature, 1998, vol. 391, issue 6665, 357-362

Abstract: Abstract The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.

Date: 1998
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DOI: 10.1038/34848

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