Reading the minor groove

Claude Hélène ()
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Claude Hélène: the Laboratoire de Biophysique, Muséum National d'Histoire Naturelle

Nature, 1998, vol. 391, issue 6666, 436-438

Abstract: One aim in drug development is to design molecules that recognize and bind to specific sequences of the DNA double helix, and can thus regulate gene expression. New work with hairpin polyamides, in which the molecules incorporate a code that recognizes all four Watson-Crick base pairs in the minor groove of DNA, provides another step towards this goal. But the achievement of specificity is offset to some extent by an increase in the instability of the interactions.

Date: 1998
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DOI: 10.1038/35026

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