Death cycle and Swiss army knives

Michael O. Hengartner ()
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Michael O. Hengartner: Cold Spring Harbor Laboratory

Nature, 1998, vol. 391, issue 6666, 441-442

Abstract: When a cell starts to undergo programmed cell death, cytochromec moves from the mitochondria, where it usually acts in an electron-transfer chain, to the cytosol. One of the relatively recent dogmas of apoptosis is that the death-suppressing protein Bcl-2 acts before cytochrome c in this pathway. But two new papers could overturn this dogma, by showing that Bcl-2 can also protect cells after cytochrome chas been released.

Date: 1998
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DOI: 10.1038/35036

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