Paraflagellar rod is vital for trypanosome motility

Philippe Bastin (), Trevor Sherwin () and Keith Gull ()
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Philippe Bastin: School of Biological Sciences, University of Manchester, 2.205 Stopford Building
Trevor Sherwin: School of Biological Sciences, University of Manchester, 2.205 Stopford Building
Keith Gull: School of Biological Sciences, University of Manchester, 2.205 Stopford Building

Nature, 1998, vol. 391, issue 6667, 548-548

Abstract: Abstract African trypanosomes are protozoan parasites that cause sleeping sickness in man. In addition to the axoneme, their flagellum contains a large structure called the paraflagellar rod (PFR) whose function is unknown. We used an antisense RNA approach to produce a specific molecular ablation of the PFR structure. The mutant cells are paralysed, demonstrating that the PFR has an essential role in cell motility.

Date: 1998
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DOI: 10.1038/35300

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