Unmasking the killer's accomplice

Marco Colonna ()
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Marco Colonna: Marco Colonna is at the Basel Institute for Immunology

Nature, 1998, vol. 391, issue 6668, 642-643

Abstract: One way in which our immune system detects virally infected cells is by monitoring levels of class I major histocompatibility complex (MHC). In infected cells, class I expression is downregulated, acting as a signal to the natural killer (NK) cells to target that cell for destruction. But some class I homologues stimulate — rather than inhibit — the NK cells, and one group has now found out why. They have discovered a signal-transducing adaptor molecule called DAP12, which couples recognition of class I MHC to an activating signal-transduction pathway.

Date: 1998
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DOI: 10.1038/35515

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