Immunology Signal sequences stop killer cells

Eric O. Long ()
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Eric O. Long: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Nature, 1998, vol. 391, issue 6669, 741-743

Abstract: During protein synthesis, many proteins destined to be carried to the cell surface are tagged with a so-called signal sequence which guides their translocation into the endoplasmic reticulum. Once that job had been done, such sequences were thought to be redundant. A striking and unexpected twist comes in the form of the discovery that signal sequences have a highly specific function in immune recognition through the agency of class I molecules of the major histocompatibility complex. It turns out that they have a central place in controlling the tolerance of types of lymphocytes known as natural killer cells to the body's own tissues.

Date: 1998
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DOI: 10.1038/35739

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