Functional genomics Double-stranded RNA poses puzzle

Richard W. Wagner () and Lin Sun
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Richard W. Wagner: Phylos Inc.
Lin Sun: Phylos Inc.

Nature, 1998, vol. 391, issue 6669, 744-745

Abstract: To study the function of genes, we need to be able to turn them on and off. A surprising new way of doing this in the nematode wormCaenorhabditis eleganshas just been reported. Double-stranded RNA that is complementary to a specific worm gene is injected into the gonads of adult animals, resulting in the production of progeny that do not express that gene. The technique is specific and reproducible at the levels of phenotype, RNA and protein.

Date: 1998
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DOI: 10.1038/35750

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