Neural patterning Deconstructing the organizer

A. Ruiz i Altaba ()
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A. Ruiz i Altaba: Skirball Institute, Developmental Genetics Program, NYU Medical Center

Nature, 1998, vol. 391, issue 6669, 748-749

Abstract: Since it was discovered over 70 years ago, the ‘organizer’ has been regarded as a group of cells that produces the signals that induce development of neural tissue. Indeed it does, but a new paper shows that it is just one of what could be a series of organizing centres that specify initial patterning of the central nervous system along the anteroposterior and forebrain-to-spinal-cord axes. Unlike the organizer, which is found posterior to the neural ectoderm, the new centre is found at the prospective anterior end of the zebrafish neuraxis.

Date: 1998
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DOI: 10.1038/35761

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