Key clockwork component cloned

Richard W. Tsien ()
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Richard W. Tsien: Stanford University Medical Center

Nature, 1998, vol. 391, issue 6670, 839-841

Abstract: The body has many repetitive electrical activities — such as brain waves — that depend on the rhythmic firing of neurons. This is achieved, in part, by the action of T-type calcium channels, inappropriate activity of which can lead to epileptic seizures. Understanding of how these channels work should now be advanced with the cloning of one T-type subunit, known as α1G. And this could lead to the development of agents that treat hypertension by specifically blocking these channels.

Date: 1998
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DOI: 10.1038/35981

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