Chaperoning brain diseases

William J. Welch () and Pierluigi Gambetti ()
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William J. Welch: Medicine and Physiology, University of California at San Francisco
Pierluigi Gambetti: Institute of Pathology, Case Western Reserve University

Nature, 1998, vol. 392, issue 6671, 23-24

Abstract: Prion diseases and neurodegenerative conditions such as Alzheimer's and Parkinson's have much in common — both seem to involve proteins which, when destabilized by (for example) genetic mutations, change conformation to form insoluble, pathogenic aggregates. Two papers now ask whether molecular chaperones might be involved in these folding changes, and they show that heat-shock proteins and prions can, indeed, interact in vitro.

Date: 1998
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DOI: 10.1038/32049

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