Synthetic ligands point to cell surface strategies

Eva J. Gordon, William J. Sanders and Laura L. Kiessling ()
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Eva J. Gordon: University of Wisconsin-Madison
William J. Sanders: University of Wisconsin-Madison
Laura L. Kiessling: University of Wisconsin-Madison

Nature, 1998, vol. 392, issue 6671, 30-31

Abstract: Abstract Protein shedding, the proteolytic release of a cell surface protein, can serve a regulatory role by liberating soluble molecules into circulation while decreasing their concentration on the cell surface1. We have created a new class of multivalent ligands, ‘neoglycopolymers’, which are designed to promote the proteolytic cleavage of a cell adhesion molecule involved in the inflammatory response, L-selectin2. These synthetic ligands induce the release of the extracellular portion of L-selectin by appropriating an endogenous protease; such activities suggest new strategies to generate anti-inflammatory agents and regulate the cell surface.

Date: 1998
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DOI: 10.1038/32073

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