Transcription and the broken heart

Garry P. Nolan ()
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Garry P. Nolan: Stanford University School of Medicine

Nature, 1998, vol. 392, issue 6672, 129-130

Abstract: An astonishing 1% of babies have some form of congenital heart defect, and the genetic cause behind one class of cardiac disorder has now been identified. Two groups independently disrupted theNF-ATcgene in mice, and found that the resultant embryos showed severe defects in cardiac valve and septum formation, leading to death after 14-15 days' gestation. The result was a big surprise, as NF-ATc protein had previously been implicated as a transcriptional regulator within activated T cells.

Date: 1998
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DOI: 10.1038/32290

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