A checkpoint on the road to cancer

Terry L. Orr-Weaver and Robert A. Weinberg
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Terry L. Orr-Weaver: MIT
Robert A. Weinberg: MIT

Nature, 1998, vol. 392, issue 6673, 223-224

Abstract: Mutations that disrupt a cell-division checkpoint, thereby causing alterations in chromosome number, have been identified in cancer cells. The accompanying increase in mutability helps to explain how tumours acquire large numbers of mutant genes during their development.

Date: 1998
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DOI: 10.1038/32520

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