Life without leptin

Stephen O'Rahilly ()
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Stephen O'Rahilly: University of Cambridge

Nature, 1998, vol. 392, issue 6674, 330-331

Abstract: Leptin is known to be involved in the control of body fat, but does it have any other functions? Two studies of human families with disrupted leptin function — one through mutations in the leptin receptor and one through mutations in leptin itself — indicate that the answer is ‘yes’. As well as being morbidly obese, young adults in both families have impaired reproductive function and they do not seem to have gone through puberty.

Date: 1998
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DOI: 10.1038/32769

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