Substance P equals pain substance?

Leslie Iversen ()
Additional contact information
Leslie Iversen: University of Oxford

Nature, 1998, vol. 392, issue 6674, 334-335

Abstract: Circumstantial evidence has led to the theory that substance P (SP) — an undecapeptide discovered over 60 years ago — is involved in the transmission of pain information from the central nervous system. More direct evidence is now provided by two studies of mice in which the function of SP has been genetically disrupted. Both studies find that the animals show reduced responses to painful stimuli, indicating that SP acts as a chemical neurotransmitter or modulator along pain pathways. Moreover, the mice show a reduced stress response when they're dunked in cold water, indicating that SP may also be involved in the response to stress.

Date: 1998
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/32776 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:392:y:1998:i:6674:d:10.1038_32776

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/32776

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().