Steroids tickle cells inside and out

Didier Picard ()
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Didier Picard: the Département de Biologie Cellulaire, Université de Genève

Nature, 1998, vol. 392, issue 6675, 437-438

Abstract: Steroid hormones are classically thought to bind to receptors inside cells, acting through changes in gene expression. But a study of the hormone progesterone shows that it can also act on the outside of a cell. The authors have found that it can bind the oxytocin receptor, preventing the natural ligand — oxytocin — from binding. Because progesterone is involved in maintaining pregnancy whereas oxytocin has the opposite effect, inducing uterine contractions, these findings could be used in preventing pre-term labour.

Date: 1998
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DOI: 10.1038/33014

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