Domains of rasGAP and rhoGAP are related

Benjamin Bax ()
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Benjamin Bax: Birkbeck College

Nature, 1998, vol. 392, issue 6675, 447-447

Abstract: Abstract Guanine-nucleotide-binding (G) proteins are ‘switched off’ by the hydrolysis of their bound GTP. The GTP bound to the G protein Ras is hydrolysed intrinsically at a very slow rate1, so, in vivo, Ras is turned off by GTPase-activating proteins (GAPs). The structures of GTPase-activating domains (GAP domains), which usually occur as parts of larger proteins, indicate that the Ras and Rho families of small G proteins and their GAPs evolved in parallel.

Date: 1998
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DOI: 10.1038/33040

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