Meningitis bacterium is viable without endotoxin

Liana Steeghs, Ronald den Hartog, Arie den Boer, Bert Zomer, Paul Roholl and Peter van der Ley ()
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Liana Steeghs: National Institute of Public Health and the Environment, RIVM
Ronald den Hartog: National Institute of Public Health and the Environment, RIVM
Arie den Boer: National Institute of Public Health and the Environment, RIVM
Bert Zomer: National Institute of Public Health and the Environment, RIVM
Paul Roholl: National Institute of Public Health and the Environment, RIVM
Peter van der Ley: National Institute of Public Health and the Environment, RIVM

Nature, 1998, vol. 392, issue 6675, 449-449

Abstract: Abstract The outer membrane of Gram-negative bacteria contains lipopolysaccharide (LPS) as its outer monolayer. This is anchored to the membrane by lipid A, which is responsible for LPS's activity as an endotoxin1. In Escherichia coli, conditionally lethal mutants have been reported for the genes involved in the early steps of lipid A biosynthesis2, suggesting that this part of the LPS molecule is essential for bacterial growth. However, we have isolated a mutant of Neisseria meningitidis which is viable in spite of an early block in lipid A biosynthesis that causes a loss of endotoxin activity.

Date: 1998
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DOI: 10.1038/33046

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