Putting the Parkin into Parkinson's

Robert L. Nussbaum ()
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Robert L. Nussbaum: the National Human Genome Research Institute

Nature, 1998, vol. 392, issue 6676, 544-545

Abstract: Parkinson's disease is characterized by parkinsonism — rigidity, resting tremor and slowness in initiating and carrying out movement. The gene for a rare autosomal recessive form of parkinsonism (AR-JP) has now been cloned and, although AR-JP differs in some respects from Parkinson's disease, the new gene could help to shed light on the causes of Parkinson's. Termedparkin, the gene has a ubiquitin homology domain, indicating that a defect in proteasome function could be involved in Parkinson's disease.

Date: 1998
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DOI: 10.1038/33271

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