A proteolytic system that compensates for loss of proteasome function

Rickard Glas, Matthew Bogyo, John S. McMaster, Maria Gaczynska and Hidde L. Ploegh ()
Additional contact information
Rickard Glas: Center for Cancer Research, Massachusetts Institute of Technology
Matthew Bogyo: Center for Cancer Research, Massachusetts Institute of Technology
John S. McMaster: Center for Cancer Research, Massachusetts Institute of Technology
Maria Gaczynska: Center for Cancer Research, Massachusetts Institute of Technology
Hidde L. Ploegh: Center for Cancer Research, Massachusetts Institute of Technology

Nature, 1998, vol. 392, issue 6676, 618-622

Abstract: Abstract Proteolysis is essential for the execution of many cellular functions. These include removal of incorrectly folded or damaged proteins1, the activation of transcription factors2, the ordered degradation of proteins involved in cell cycle control3, and the generation of peptides destined for presentation by class I molecules of the major histocompatibility complex4. A multisubunit protease complex, the proteasome5, accomplishes these tasks. Here we show that in mammalian cells inactivation of the proteasome by covalent inhibitors allows the outgrowth of inhibitor-resistant cells. The growth of such adapted cells is apparently maintained by the induction of other proteolytic systems that compensate for the loss of proteasomal activity.

Date: 1998
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/33443 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:392:y:1998:i:6676:d:10.1038_33443

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/33443

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().