Pulling the fly's leg

Ginés Morata () and Ernesto Sánchez-Herrero
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Ginés Morata: the Centro de Biologia Molecular, CSIC-UAM Universidad Autnoma de Madrid
Ernesto Sánchez-Herrero: the Centro de Biologia Molecular, CSIC-UAM Universidad Autnoma de Madrid

Nature, 1998, vol. 392, issue 6677, 657-658

Abstract: Genetic control of development rests with the so-called homeotic (Hox) genes, mutations in which often result in spectacular phenotypes. For example,Antennapedia (Antp) mutant fruit flies develop legs where the antennae should be. But a new study shows that, contrary to previous thinking, Antp does not specify leg development — indeed, it is not even required to make a leg. Instead, Antp prevents the functioning of the homothoraxgene, a Hox gene that is responsible for antenna development.

Date: 1998
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DOI: 10.1038/33547

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