Allosteric effects of DNA on transcriptional regulators

Jeffrey A. Lefstin () and Keith R. Yamamoto
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Jeffrey A. Lefstin: University of California San Francisco
Keith R. Yamamoto: University of California San Francisco

Nature, 1998, vol. 392, issue 6679, 885-888

Abstract: Abstract Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is appropriate to an individual gene.

Date: 1998
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DOI: 10.1038/31860

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