Transcription sans TBP

Lynne M. Apone and Michael R. Green ()
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Lynne M. Apone: the Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical Center
Michael R. Green: the Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical Center

Nature, 1998, vol. 393, issue 6681, 114-115

Abstract: Several general ‘rules’ have emerged over the years about the requirements for transcription of genes. One of these was that the TATA-binding protein (TBP) is essential, both for initiation of transcription by recognizing the promoter, and for assembly of transcription complexes. A new study looks set to overturn this dogma by identifying a complex that does not contain TBP (the so-called TBP-free TAFII-containing complex, TFTC) yet can still support transcription.

Date: 1998
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DOI: 10.1038/30097

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