Imprinted gene in postnatal growth role

Jean-Michel Itier, Günter L. Tremp, Jean-François Léonard, Marie-Christine Multon, Gwénaëlle Ret, Fabien Schweighoffer, Bruno Tocqué, Marie-Thérèse Bluet-Pajot, Valérie Cormier and François Dautry
Additional contact information
Jean-Michel Itier: Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville
Günter L. Tremp: Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville
Jean-François Léonard: Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville
Marie-Christine Multon: Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville
Gwénaëlle Ret: Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville
Fabien Schweighoffer: BioScreen Therapeutics
Bruno Tocqué: BioScreen Therapeutics
Marie-Thérèse Bluet-Pajot: Biodynamique des Systémes Neuroendocriniens, INSERM U-159
Valérie Cormier: Unité de Recherches sur les Handicaps Génétiques de l Enfant, INSERM U-393
François Dautry: Génétique Moléculaire et Intégration des Fonctions Cellulaires, CNRS UPR 9044, Institut de Recherches sur le Cancer

Nature, 1998, vol. 393, issue 6681, 125-126

Abstract: Abstract Mice that have been specially bred to lack a protein known as Grf-1, which is normally found only in the brain, do not grow properly after they are born and remain small all their lives. We have now identified a function of Grf-1 as an important regulator of the synthesis and release of growth hormone. Moreover, grf1, the gene encoding this protein, is unlike other imprinted genes that affect growth because it operates after, rather than before, birth.

Date: 1998
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DOI: 10.1038/30120

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