Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila

Michel Gho () and François Schweisguth
Additional contact information
Michel Gho: Laboratoire de G´nétique du Développement de la Drosophile
François Schweisguth: Laboratoire de G´nétique du Développement de la Drosophile

Nature, 1998, vol. 393, issue 6681, 178-181

Abstract: Abstract During metazoan development, cell-fate diversity is brought about, in part, by asymmetric cell divisions1. In Drosophila, bristle mechanosensory organs are composed of four different cells that originate from a single precursor cell, pI, after two rounds of asymmetric division2. At each division, distinct fates are conferred on sister cells by the asymmetric segregation of Numb, a negative regulator of Notch signalling3,4,5,6. Here we show that the orientation of the mitotic spindles and the localization of the Numb crescent follow a stereotyped pattern. Mitosis of pI is orientated parallel to the anteroposterior axis of the fly. We show that signalling mediated by the Frizzled receptor polarizes pI along this axis, thereby specifying the orientation of the mitotic spindle and positioning the Numb crescent. The mitoses of the two cells produced by mitosis of pI are orientated parallel and orthogonal, respectively, to the division axis of pI. This difference in cell-division orientation is largely independent of the identity of the secondary precursor cells, and is regulated by Frizzled-independent mechanisms.

Date: 1998
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/30265 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:393:y:1998:i:6681:d:10.1038_30265

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/30265

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().