Working backwards to find answers

Jean-Claude Meunier ()
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Jean-Claude Meunier: Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique

Nature, 1998, vol. 393, issue 6682, 211-212

Abstract: Reverse pharmacology is a way of identifying biologically active molecules by starting with the receptors to which they bind and, literally, working backwards. One group has gone even further back than this — first they cloned an ‘orphan’ receptor and then they set about looking for its ligand. They identified two peptides that bind this receptor, and have found that these promote the release of prolactin — the hormone that is responsible for lactation.

Date: 1998
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DOI: 10.1038/30347

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