Papillomavirus and p53

Harald zur Hausen ()
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Harald zur Hausen: the Deutsches Krebsforschungszentrum

Nature, 1998, vol. 393, issue 6682, 217-217

Abstract: Certain types of human papillomavirus (HPV) are involved in the development of cervical and other perianal cancers, and a new study takes us a step closer to working out how. An HPV-encoded oncoprotein known as E6 can interact with the human tumour suppressor p53, inactivating it and preventing it from carrying out its normal functions. The authors have found that people can carry either an arginine or a proline residue at a specific position in p53, and that E6 binds best to the arginine form. What's more, they've found that people with two copies of the p53 gene that specifies the arginine residue have a seven-fold higher risk of developing cervical cancer than those without.

Date: 1998
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DOI: 10.1038/30363

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