Human gene for physical performance

H. E. Montgomery, R. Marshall, H. Hemingway, S. Myerson, P. Clarkson, C. Dollery, M. Hayward, D. E. Holliman, M. Jubb, M. World, E. L. Thomas, A. E. Brynes, N. Saeed, M. Barnard, J. D. Bell, K. Prasad, M. Rayson, P. J. Talmud and S. E. Humphries
Additional contact information
H. E. Montgomery: University College London Centre for Cardiovascular Research, Rayne Institute
R. Marshall: University College London Centre for Cardiovascular Research, Rayne Institute
H. Hemingway: University College London Centre for Cardiovascular Research, Rayne Institute
S. Myerson: University College London Centre for Cardiovascular Research, Rayne Institute
P. Clarkson: University College London Hospital
C. Dollery: University College London Hospital
M. Hayward: University College London Hospital
D. E. Holliman: Centre for Human Sciences
M. Jubb: Royal Defence Medical College, HMS Dolphin
M. World: Royal Defence Medical College, HMS Dolphin
E. L. Thomas: Imperial College School of Medicine MRI Unit
A. E. Brynes: Imperial College School of Medicine MRI Unit
N. Saeed: Imperial College School of Medicine MRI Unit
M. Barnard: Imperial College School of Medicine MRI Unit
J. D. Bell: Imperial College School of Medicine MRI Unit
K. Prasad: St Georges Hospital
M. Rayson: Optimal Performance
P. J. Talmud: University College London Centre for Cardiovascular Genetics, Rayne Institute
S. E. Humphries: University College London Centre for Cardiovascular Genetics, Rayne Institute

Nature, 1998, vol. 393, issue 6682, 221-222

Abstract: Abstract A specific genetic factor that strongly influences human physical performance has not so far been reported, but here we show that a polymorphism in the gene encoding angiotensin-converting enzyme does just that. An ‘insertion’ allele of the gene is associated with elite endurance performance among high-altitude mountaineers. Also, after physical training, repetitive weight-lifting is improved eleven-fold in individuals homozygous for the ‘insertion’ allele compared with those homozygous for the ‘deletion’ allele.

Date: 1998
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DOI: 10.1038/30374

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