A short cut to the nucleus

Julian Lewis ()
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Julian Lewis: the Imperial Cancer Research Fund

Nature, 1998, vol. 393, issue 6683, 304-305

Abstract: The signals that pass between cells to coordinate the construction of our bodies during development are surprisingly simple and few. One of the main signalling pathways involves a protein called Notch. A puzzle for those working on this protein is how it relays signals from the surface of the cell —where it is bound into the membrane —to the nucleus. Three groups have now found the solution, using different approaches. It turns out that on activation by its ligand, Delta, the Notch protein is cleaved, and only the intracellular domain goes on to the nucleus.

Date: 1998
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DOI: 10.1038/30597

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