Methylation meets acetylation

Timothy H. Bestor ()
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Timothy H. Bestor: College of Physicians and Surgeons of Columbia University

Nature, 1998, vol. 393, issue 6683, 311-312

Abstract: Females have two copies of the X chromosome, yet the genes on only one copy are active. Genes on the other copy are turned off by cytosine methylation. For the first time, a link has been found between this methylation process and acetylation of histones —the protein balls around which the DNA in chromosomes is wrapped. A protein called MeCP2, which binds only to methylated DNA sequences, exists in a complex with histone deacetylase, which removes acetyl groups from the histones, causing them to condense and become transcriptionally inactive.

Date: 1998
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DOI: 10.1038/30613

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