RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

Linda M. McLatchie, Neil J. Fraser, Martin J. Main, Alan Wise, Jason Brown, Nicola Thompson, Roberto Solari, Melanie G. Lee and Steven M. Foord ()
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Linda M. McLatchie: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
Neil J. Fraser: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
Martin J. Main: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
Alan Wise: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
Jason Brown: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
Nicola Thompson: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
Roberto Solari: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
Melanie G. Lee: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre
Steven M. Foord: Receptor Systems and Cell Biology Units, GlaxoWellcome Medicines Research Centre

Nature, 1998, vol. 393, issue 6683, 333-339

Abstract: Abstract Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.

Date: 1998
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DOI: 10.1038/30666

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