Licence to kill

Antonio Lanzavecchia ()
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Antonio Lanzavecchia: the Basel Institute for Immunology

Nature, 1998, vol. 393, issue 6684, 413-414

Abstract: To kill invading pathogens, the immune system often has to kill its own infected cells. But how does it control this potentially dangerous mechanism? Three groups have done experiments that support one model of T-cell activation. T-helper cells recognize a specific antigen on professional antigen-presenting cells (APCs), and deliver a signal that activates, or 'licenses', the APC. This activated APC can then stimulate the T-killer cells to mount a response against that antigen.

Date: 1998
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DOI: 10.1038/30845

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