Help for cytotoxic-T-cell responses is mediated by CD40 signalling

Sally R. M. Bennett, Francis R. Carbone (), Freda Karamalis, Richard A. Flavell, Jacques F. A. P. Miller and William R. Heath ()
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Sally R. M. Bennett: The Walter and Eliza Hall Institute of Medical Research
Francis R. Carbone: The Monash Medical School
Freda Karamalis: The Walter and Eliza Hall Institute of Medical Research
Richard A. Flavell: The Section of Immunology and Howard Hughes Medical Institute, Yale University
Jacques F. A. P. Miller: The Walter and Eliza Hall Institute of Medical Research
William R. Heath: The Walter and Eliza Hall Institute of Medical Research

Nature, 1998, vol. 393, issue 6684, 478-480

Abstract: Abstract Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are presented on target cells by the class I major histocompatibility complex. CTLs are responsible for the killing of antigen-bearing target cells, such as virus-infected cells. Although CTL effectors can act alone when killing target cells, their differentiation from naive CD8-positive T cells is often dependent on ‘help’ from CD4-positive helper T (TH) cells1,2,3,4. Furthermore, for effective CTL priming, this help must be provided in a cognate manner, such that both the TH cell and the CTL recognize antigen on the same antigen-presenting cell2,4. One explanation for this requirement is that TH cells are needed to convert the antigen-presenting cell into a cell that is fully competent to prime CTL5. Here we show that signalling through CD40 on the antigen-presenting cells can replace the requirement for TH cells, indicating that T-cell ‘help’, at least for generation of CTLs by cross-priming, is mediated by signalling through CD40 on the antigen-presenting cell.

Date: 1998
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DOI: 10.1038/30996

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