A family of hyperpolarization-activated mammalian cation channels

Andreas Ludwig, Xiangang Zong, Michael Jeglitsch, Franz Hofmann and Martin Biel ()
Additional contact information
Andreas Ludwig: Institut für Pharmakologie und Toxikologie, Technische Universität München
Xiangang Zong: Institut für Pharmakologie und Toxikologie, Technische Universität München
Michael Jeglitsch: Institut für Pharmakologie und Toxikologie, Technische Universität München
Franz Hofmann: Institut für Pharmakologie und Toxikologie, Technische Universität München
Martin Biel: Institut für Pharmakologie und Toxikologie, Technische Universität München

Nature, 1998, vol. 393, issue 6685, 587-591

Abstract: Abstract Pacemaker activity of spontaneously active neurons1,2,3 and heart cells4,5,6 is controlled by a depolarizing, mixed Na+/K+ current, named Ih (or If in the sinoatrial node of the heart)1,4. This current is activated on hyperpolarization of the plasma membrane. In addition to depolarizing pacemaker cells, Ih is involved in determining the resting membrane potential of neurons1,2 and provides a mechanism to limit hyperpolarizing currents in these cells7,8,9. Hormones and neurotransmitters that induce a rise in cyclic AMP levels increase Ih by a mechanism that is independent of protein phosphorylation, and which involves direct binding of the cyclic nucleotide to the channel that mediates Ih10,11,12,13. Here we report the molecular cloning and functional expression of the gene encoding a hyperpolarization-activated cation channel (HAC1) that is present in brain and heart. This channel exhibits the general properties of Ih channels. We have also identified full-length sequences of two related channels, HAC2 and HAC3, that are specifically expressed in the brain, indicating the existence of a family of hyperpolarization-activated cation channels.

Date: 1998
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/31255 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:393:y:1998:i:6685:d:10.1038_31255

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/31255

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().