New cogwheels in the clockworks

Ueli Schibler ()
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Ueli Schibler: University of Geneva

Nature, 1998, vol. 393, issue 6686, 620-621

Abstract: The emerging picture of how autonomous circadian clocks are regulated has been built up from studies in a number of organisms. Four papers now report the identification of one mouse protein — calledClock — in the fruitfly Drosophila melanogaster. Moreover the researchers concerned have found that, in both mice and flies, Clockacts as a heterodimer with a protein dubbed Cycle, and that the two together activate the transcription of the per and tim genes.

Date: 1998
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DOI: 10.1038/31337

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