SMAD proteins and mammalian anatomy

Rik Derynck ()
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Rik Derynck: Programs in Cell Biology and Developmental Biology, University of California at San Francisco

Nature, 1998, vol. 393, issue 6687, 737-739

Abstract: Members of the transforming growth factor-β (TGF-β) family, which signal through SMAD proteins, are involved in many developmental processes. Inactivation of the genes encoding two of the SMAD proteins, Smads 2 and 4, shows that both are required to lay down some of the primary layers of the animal body. Smad2 also seems to act in anterior-posterior patterning and the development of left-right asymmetry.

Date: 1998
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DOI: 10.1038/31593

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