Boning up on Hedgehog's movements

Philip W. Ingham ()
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Philip W. Ingham: the Developmental Genetics Programme, The Krebs Institute, University of Sheffield

Nature, 1998, vol. 394, issue 6688, 16-17

Abstract: So far, six proteins have been identified as members of the Hedgehog family — intercellular signals that act in a range of developmental processes. One group now reports the discovery of a seventh member in the fruitflyDrosophila melanogaster. Called tout-velu, the newly identified protein mediates diffusion of the Hedgehog protein in the Drosophila wing. What's more, the tout-velugene is homologous to two human genes, mutations in which are associated with benign bone tumours.

Date: 1998
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DOI: 10.1038/27764

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