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The two faces of glutamate

Jean-Philippe Pin ()
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Jean-Philippe Pin: the CNRS-UPR 9023, Mécanismes Moléculaires des Communications Cellulaires, CCIPE

Nature, 1998, vol. 394, issue 6688, 19-20

Abstract: Most of the excitatory synapses in our brain — those that cause the depolarization of neurons — involve release of the neurotransmitter glutamate. One group has now found that glutamate also has inhibitory actions, resulting in the opposite effect (hyperpolarization). What's more, glutamate can act on the same receptor to cause both effects. It turns out that the crucial factors are how much glutamate is present, and how rapidly it is applied.

Date: 1998
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DOI: 10.1038/27771

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