G-protein diseases furnish a model for the turn-on switch

Taroh Iiri, Zvi Farfel and Henry R. Bourne ()
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Taroh Iiri: University of California
Zvi Farfel: Sheba Medical Center, Tel Aviv University
Henry R. Bourne: University of California

Nature, 1998, vol. 394, issue 6688, 35-38

Abstract: Abstract How does a trimeric G protein on the inside of a cell membrane respond to activation by a transmembrane receptor? G-protein mutations in patients with hypertension and inherited endocrine disorders enhance or block signals from stimulated receptors. In combination with three-dimensional crystal structures and results from biochemical experiments, the phenotypes produced by these mutations suggest a model for the molecular activation mechanism that relays hormonal and sensory signals transmitted by many transmembrane receptors.

Date: 1998
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DOI: 10.1038/27831

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